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Shaanxi
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2023-04-24 22:06
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Company Profile
Xi'an Yihui Bio-technology Co., LtdBy certification [File Integrity]
Contact:yihuisw(Mr.)
Email:
Telephone:
Phone:
Area:Shaanxi
Address:Shaanxi
Website:http://www.yihuipharm.com/ http://yihuisw.ahzy315.com/
What is Clotrimazole?
99% Clotrimazole is a broad-spectrum antifungal agent that can also be used to treat protozoan infections. Its chemical name is 1-[β-(2, 4-dichlorophenyl) -cyclopropyl] -4-methyl-1H-imidazole,CAS NO. Is 23593-75-1. which is a white or white-like crystalline powder that is easily soluble in organic solvents such as water, ethanol and chloroform.
The main raw material for clotrimazole api production is Bulgarian lichen (also known as basil lichen). Bulgarian lichen is a strain in the order Cyanobacteria of the class Cyanobacteria of the phylum gonadae that can be cultured by fermentation to produce it. The preparation process includes: using Bulgarian lichen as raw material, using microbial fermentation technology to culture the mycelium containing clotrimazole, and then the fermentation filtrate separation, extraction, crystallization and other steps, and finally obtain high purity clotrimazole.
It is available in tablet, capsule, injection and other forms. Its main mechanism is to interfere with the synthesis of fungal cell wall and membrane, and prevent fungal growth and reproduction. In clinical application, It is often used to treat fungal infections caused by candida and Candida albicans, as well as protozoan infections such as Trichomonas vaginalis.
It is a broad-spectrum antifungal agent that can be used to treat a variety of fungal infections, such as skin, hair, and nail fungal infections, oral candidiasis, and urogenital tract fungal infections. Its discovery dates back to the 1960s.
At the time, Johnson & Johnson scientists were studying the molecular structure of streptomycin antibiotics and discovered that some of the compounds also had antifungal properties. After many tests and chemical modifications, they succeeded in making it and finally brought it to market in 1976, where it was approved for sale in Europe and the United States.
Because clotrimazole has strong fungal inhibition ability, so it was soon used in clinical treatment of fungal infection cases, and achieved a good effect. In addition, due to its special molecular structure, it can also inhibit the synthesis and metabolism of male hormones, making it an important drug for the treatment of male hair loss and some female breast cancer. It has been widely used in various clinical treatments because of its broad spectrum, high efficiency and safety, and has become the leader among many antifungal drugs.
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Basic Information
Appearance |
White to pale yellow, crystalline powder |
Melting point |
147-149°C |
Structural formula: |
CAS NO. |
23593-75-1 |
Boiling point |
501.14°C (rough estimate) |
|
MF |
C22H17ClN2 |
Density |
1.1095 (rough estimate) |
|
MW |
344.84 |
refractive index |
1.5940 (estimate) |
|
EINECS |
245-764-8 |
solubility Soluble |
in chloroform, DMSO, DMF and alcohols |
|
Assay |
min99% |
storage temp. |
2-8°C |
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Quality standard:
TEST ITEM |
SPECIFICATION |
1.Characteristics |
White to pale yellow, crystalline powder. Melts at about 142,with decomposition. Practically insoluble in water; freely soluble in methanol, in acetone, in chloroform, and in alcohol. |
2.Identification   |
Infrared Absorption <197> |
The retention time of the major peak of the Sample solution corresponds to that of the Standard solution, as obtained in the Assay.(HPLC) |
|
3.Related compound A |
≤0.5% |
4.Imidazole |
≤0.5% |
5.Loss on drying |
≤0.5% |
6.Residue On Ignition |
≤0.1% |
7.Heavy Metals |
≤0.001% |
8.Assay |
98%-102%(C22H17ClN2) Calculated on dried basis |
 9.Residual Solvent |
Benzene≤2ppm |
Acetonitrile≤5000ppm |
|
10.Microorganism |
TPC<1000cfu/g |
Y and M <100cfu/g |
|
E-coli – absent |
|
Staphylococcus Aureus-Absent |
|
Pseudomonas Aeruginosa-Absent |
|
Albicans Saccharomyces-Absent |
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99% Clotrimazole is a broad-spectrum antifungal agent with the following main effects:
Inhibition of fungal growth
Elimination of fungal infections
Prevention of fungal infections
Topical treatment
In conclusion, it is a highly effective and commonly used antifungal drug with wide application value. When using it to treat or prevent fungal infections, it is necessary to strictly follow the instructions of the drug and the doctor to ensure the efficacy and safety of the treatment.
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Only for commercial or research use , not supply for any individual!
Packing:
1~2kg |
|
2-10kg |
|
10-25kg |
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Shipping:
≤50kg |
By express door to door Fedex, DHL,UPS,TNT,EMS ect. Fast and convenient |
|
50kg~200kg |
By air Fast and cheap |
|
≥200kg |
By sea Cheapest way |
|
Or as your requirement to choose the cheapest way or the fast. |
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Xi 'an Yihui company’s sales office, production equipment
High level of research and development ability
Advanced production equipment and technology
Perfect after-sales service
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Xi’an Yihui company is a professional enterprise engaged in the research and development, production and sales of pharmaceutical raw materials, as well as one of the professional manufacturers of clotrimazole api. The company is committed to the research and development of high quality biologic drugs and innovative drugs, with a wide range of market channels and customer groups. Xi 'an Yihui Company has more than 10 years of production experience in the production of 99% clotrimazole, with advanced production equipment and technology. At the same time, we strictly control the procurement of raw materials and the production process to ensure the quality and stability of products. Clotrimazole provided by Xi 'an Yihui Company are mainly used in the pharmaceutical industry of antifungal drugs, widely used in the treatment of dandruff, oral leukopleckles, skin fungal infections and other diseases. Companies adhering to the advanced scientific and technological concepts, pay attention to originality and innovation ability, improve their own competitive advantages in the pharmaceutical industry, in order to meet the needs of the market.
http://www.yihuipharm.com/